Azithromycin treatment of drug induced gingival hyperplasia in renal transplant patients
نویسندگان
چکیده
Material & Methods: Patients diagnosed with early to moderate gingival overgrowth with stable allograft function were included in the study. These patients had been taking either cyclosporine or tacrolimus for more than 6 months. The patients were randomized equally into three groups. Two groups had received 500-mg azithromycin for 5-days given at baseline only. While the control group received placebo in addition to the oral hygiene program .The clinical periodontal parameters were assessed and included the plaque index, bleeding on probing index, the gingival overgrowth index, and the probing depth. They were evaluated at the baseline and at flow up time (1, 3, 6 months).
منابع مشابه
Treatment of cyclosporin-induced gingival hyperplasia with azithromycin.
BACKGROUND Gingival hyperplasia is a known complication of cyclosporin therapy. Although plaque control has been shown to be of benefit, gingival surgery is occasionally necessary. The aim of this study was to review the effect of a short-course therapy with azithromycin in renal transplant patients with cyclosporin-induced gingival hyperplasia. METHODS Thirty-eight patients received 500 mg/d...
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Statement of Problem: Gingival overgrowth is a side effect commonly induced by Cyclosporin treatment. The effects of Azithromycin, a macrolidic antibiotic, has been focused on gingival enlargement treatment induced by cyclosporine in numerous articles. Purpose: The goal of the present study was to survey the effects of systemic Azithromycin in the treatment of gingival overgrowth induced by cyc...
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Azithromycin is effective for the remission of cyclosporine A-induced gingival overgrowth (CIGO) in persons who have undergone renal transplant. To explain its mechanism in alleviating the clinical symptoms of these individuals, we examined the effect of azithromycin on cell proliferation and collagen turnover modified by cyclosporin A in human gingival fibroblasts from healthy persons and from...
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Gingival overgrowth is an uncommon adverse effect of cyclosporine administration in veterinary species. In people, gingival overgrowth is a common complication of cyclosporine administration for immunosuppression, generally following transplant procedures. Azithromycin has been used successfully for managing gingival overgrowth in human transplant patients when cyclosporine administration canno...
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BACKGROUND Cyclosporin A (CsA) induces gingival overgrowth (GO) in up to a quarter of CsA-treated renal transplant recipients. A short-term therapy with azithromycin effectively reduces GO, indicating a possible involvement of microorganisms in the pathogenesis of CsA-induced GO. We aimed to determine if there could be any relationship between infection with Chlamydia pneumoniae and GO pathogen...
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